Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Article Title: Multiple antibodies targeting tumor-specific mutations redirect immune cells to inhibit tumor growth and increase survival in experimental animal models.

doi: 10.1007/s12094-019-02235-3

Figure Lengend Snippet: Fig. 3 The effect of different treatments on B16F10 tumor growth in mice. Significant tumor growth retardations (34–49%) were observed in the mice treated with effector cells armed with the nine-antibody cocktail and PD1i, as compared to PBS control group. Two-way ANOVA analysis of the data shows significantly differ- ent curves by treatment and time. *Significantly different (P ≤ 0.05) in comparison to PBS and PD1i alone groups as determined by Tukey’s multiple comparisons test. The values represent the mean ± SEM of six mice in each group. EC effector cells, EC armed with Ab Cocktail Effector cells armed with a cocktail of all the nine rabbit antibodies against selected mutated peptides, TCT tumor cell transplantation, T1– T5 EC treatment days, DPI days post-implantation

Article Snippet: Anti-mouse PD1 inhibitor antibody (PD1i) was supplied by Bio X cell (West Lebanon, NH).

Techniques: Control, Comparison, Transplantation Assay

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Article Title: Multiple antibodies targeting tumor-specific mutations redirect immune cells to inhibit tumor growth and increase survival in experimental animal models.

doi: 10.1007/s12094-019-02235-3

Figure Lengend Snippet: Fig. 4 The effect of different treatments on survival of mice implanted with B16F10 mela- noma cells. The combined treat- ment with effector cells armed with nine-antibody cocktail and PD1i increased the survival of mice. EC effector cells, EC armed with Ab Cocktail effector cells armed with a cocktail of all the nine antibodies against selected mutated peptides, TCT tumor cell transplanta- tion, T1–T5 EC treatment days, DPI days post-implantation

Article Snippet: Anti-mouse PD1 inhibitor antibody (PD1i) was supplied by Bio X cell (West Lebanon, NH).

Techniques: